Relationship between Mollicutes and spontaneous abortion: An epidemiological analysis

Table 1 Descriptive analysis of women with spontaneous abortion participating in the study, Vitória da Conquista, Bahia, Brazil, 2018

Variables	n	(%)
Placenta colonized by Mollicutes
Yes	65	73
No	24	27
Age
Up to 29 yr	52	58.5
> 29 yr	37	41.5
Marital status
With companion	68	78.2
Without companion	19	21.8
Year of study1
None	2	2.3
Up to 7 yr	29	32.9
> 7 yr	57	64.8
Origin
Rural area	28	31.5
Urban area	61	68.5
Skin color
White	27	30.3
Non-white	62	69.7
Income1,2
Up to the minimum wage	58	65.2
Above the minimum wage	30	33.6
Religion
Catholic	49	55.1
Others5	26	29.2
None	14	15.7
Changes in eating habits during pregnancy3
Yes	10	11.5
No	77	88.5
Physical activity1
Yes	16	18.2
No	72	81.8
Alcohol consumption6
Yes	14	15.7
No	75	84.3
Smoking6
Yes	4	4.5
No	85	95.5
Gynecological disorders1,7
Yes	9	88.7
No	79	10.3
Menarche
Up to 13 yr	67	75.3
> 13 yr	22	24.7
First sexual intercourse4
Up to 15 yr	30	34.9
> 15 yr	56	65.1
Number of partners1
1	53	60.2
> 1	35	39.8
Previous history of STI
Yes	5	5.6
No	84	94.4
Condom use during sexual intercourse1
No	51	57.9
Sometimes	37	42.1
Pain during intercourse
Yes	26	29.6
No	62	70.4
Pregnancies (including the current one)
Up to 2 pregnancies	53	59.5
> 2 pregnancies	36	40.5
Premature births
None	82	92.1
More than one	7	7.9
Prenatal care
Yes	52	58.4
No	37	41.6
Pregnancy was planned3
Yes	32	36.8
No	55	63.8
Number of live children
1	59	66.3
> 1	30	33.7
Presence of vaginal discharge
Yes	58	65.2
No	31	34.8
Dysuria
Yes	16	18
No	73	82
Groin swelling
Yes	4	4.5
No	85	95.5
Vaginal alteration8
Yes	9	10.1
No	80	89.9
Vaginal itching
Yes	27	30.3
No	62	69.7
Vaginal erythema
Yes	18	20.2
No	71	79.8
Pelvic pain
Yes	33	37.1
No	56	62.9
Vaginal wart
Yes	2	2.2
No	87	97.8
Vaginal wound
Yes	2	2.2
No	87	97.8

¹Non-responding.

²Minimum salary of R$ 954.00.

³Non-responders.

⁴Non-responders.

⁵Evangelical, spirit, candomblé.

⁶Any quantity and frequency.

⁷Uterine fibroids, ovarian cysts.

⁸Any anatomical or physiological change.

STI: Sexually transmitted infection.

Table 2 Univariate analysis of placental colonization by Mollicutes in spontaneous abortion and selected variables, Vitória da Conquista, Bahia, Brazil, 2018

Variable	OR (IC)	χ2	P value
Age
Up to 29 yr	7.26 (2.49-21.12)	15	0.00
> 29 yr	1
Marital status
With companion	1
Without companion	2.33 (0.62-9.08)	1.69	0.19
Year of study1
None	1
Up to 7 yr	2.27 (0.12-39.64)	0.3	0.57
> 7 yr	3.21 (0.18-54.79)	0.72	0.39
Origin
Rural area	1.15 (0.41-3.22)	0.08	0.77
Urban area	1
Skin color
White	1
Non-white	1.43 (0.49-4.13)	0.44	0.5
Income1,2
Up to the minimum wage	1.22 (0.46-3.26)	0.17	0.67
Above the minimum wage	1
Religion
Catholic	1
Others5	0.98 (0.33-2.86)	0	0.97
None	0.90 (0.24-3.28)	0.01	0.87
Changes in eating habits during pregnancy3
Yes	1
No	3.05 (0.79-11.69)	2.84	0.09
Physical activity1
Yes	1
No	1.26 (0.33-4.12)	0.15	0.69
Alcohol consumption6
Yes	5.75 (0.70-46.19)	3.31	0.06
No	1
Smoking6
Yes	1.11	0	0.92
No	1
Gynecological disorders1,7
Yes	3.28 (0.38-27.78)	1.32	0.25
No	1
Menarche
Up to 13 yr	3.15 (1.13-8.79)	5.07	0.02
> 13 yr	1
First sexual intercourse4
Up to 15 yr	2.17 (0.71-6.65)	1.93	0.16
> 15 yr	1
Number of partners1
1	2.78 (0.16-46.33)	0.55	0.45
> 1	1
Previous history of STI
Yes	1.5 (0.16-14.21)	0.13	0.71
No	1
Condom use during sexual intercourse1
No	1
Sometimes	2.14 (0.78-5.87)	2.24	0.13
Pain during intercourse
Yes	1.36 (0.47-3.95)	0.32	0.56
No	1
Pregnancies (including the current one)
Up to 2 pregnancies	2.73 (1.04-7.15)	4.36	0.03
> 2 pregnancies	1
Premature births
None	1
More than one	2.17 (0.45-10.50)	0.97	0.32
Prenatal care
Yes	1
No	1.26 (0.48-3.09)	0.22	0.63
Pregnancy was planned3
Yes	1
No	1.33 (0.50-3.48)	0.34	0.55
Number of live children
1	3.33 (1.25-8.84)	6.15	0.01
> 1	1
Presence of vaginal discharge
Yes	2.42 (0.92-6.33)	3.33	0.06
No	1
Dysuria
Yes	1.13 (0.32-3.92)	0.03	0.84
No	1
Groin swelling
Yes	1.11 (0.11-11.24)	0	0.92
No	1
Vaginal itching
Yes	1.27 (0.46-3.50)	0.22	0.63
No	1
Vaginal erythema
Yes	0.95 (0.29-3.02)	0	0.93
No	1
Pelvic pain
Yes	1.61 (0.58-4.44)	0.88	0.34
No	1

¹Non-responding.

²Minimum salary of R$ 95450.

³Non-responders.

⁴Non-respondents.

⁵Evangelical, spirit, candomblé.

⁶Any quantity and frequency.

⁷Uterine fibroids, ovarian cysts.

Table 3 Final regression model by groups of selected variables and the presence of Mollicutes in placental tissue of spontaneous abortion, Vitória da Conquista, Bahia, Brazil, 2018

Variable	OR, IC (95%)	P value
Age
Up to 29 yr	7.55 (2.37-24.03)	0.01
> 29 yr	1.0
Menarche
Up to 13 yr	3.43 (1.03-11.44)	0.04
> 13 yr	1.0
Dietary change after pregnancy
Yes	0.16 (0.03-0.06)	0.03
No	1.0

Model adequacy test-Hosmer Lemeshow, χ² = 2.37 P = 0.49. OR: Odds ratio.