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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Feb 10, 2021; 10(1): 1-15
Published online Feb 10, 2021. doi: 10.5317/wjog.v10.i1.1
Published online Feb 10, 2021. doi: 10.5317/wjog.v10.i1.1
Relationship between Mollicutes and spontaneous abortion: An epidemiological analysis
Maria Tânia Silva Oliveira, Caline Novais Teixeira Oliveira, Lucas Miranda Marques, Maria Luísa Cordeiro Santos, Fabrício Freire de Melo, Cláudio Lima Souza, Márcio Vasconcelos Oliveira, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029094, Bahia, Brazil
Lucas Santana Coelho da Silva, Hellen Braga Martins Oliveira, Raquel Sousa Freire, Universidade Estadual Santa Cruz, Universidade Estadual Santa Cruz, Ilhéus 45662900, Bahia, Brazil
Author contributions: All authors contributed equally to this paper in terms of conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Institutional review board statement: This research was approved by the Health Foundation of Vitória da Conquista and approved by the Human Research Ethics Committee of the Universidade da Federal da Bahia, Instituto Multidisciplinar em Saúde, under the opinion 1.764 332.
Conflict-of-interest statement: There is no conflict of interest associated with the contributions by any of the senior authors or coauthors to this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, MSc, PhD, Postdoc, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029094, Bahia, Brazil. freiremelo@yahoo.com.br
Received: September 24, 2020
Peer-review started: September 24, 2020
First decision: December 21, 2020
Revised: December 21, 2020
Accepted: January 8, 2021
Article in press: January 8, 2021
Published online: February 10, 2021
Peer-review started: September 24, 2020
First decision: December 21, 2020
Revised: December 21, 2020
Accepted: January 8, 2021
Article in press: January 8, 2021
Published online: February 10, 2021
Core Tip
Core Tip: This study analyzed the association between spontaneous abortion and placental colonization by Mollicutes using a cross-sectional design, which involved the collection of data and biological material from women hospitalized due to spontaneous abortion or term delivery. Microbial identification in biological samples was performed by real-time polymerase chain reaction and the collected data were used to perform descriptive, univariate and multivariate analyses. The prevalence of Mollicutes among women who had spontaneous abortion was 73.0% and in women who had an abortion, an 8.12-fold risk of placental colonization by at least one species of Mollicutes was observed, compared to those who completed pregnancy.