Observational Study
Copyright ©The Author(s) 2016.
World J Obstet Gynecol. May 10, 2016; 5(2): 187-196
Published online May 10, 2016. doi: 10.5317/wjog.v5.i2.187
Table 3 Cox proportional hazard model of time-to-death among ovarian cancer patients
PredictorModel 11
Model 21
Hazard ratio (95%CI)P valueHazard ratio (95%CI)P value
Received surgery SOC2
Yes1.001.00
No1.22 (1.12-1.33)< 0.011.21 (1.11-1.31)< 0.01
Received chemotherapy SOC24
Yes1.004
No, but received some chemotherapy0.95 (0.89-1.02)0.184
Received no chemotherapy1.29 (1.14-1.46)< 0.014
Age at diagnosis
66-691.001.00
70-741.07 (0.98-1.17)0.131.05 (0.97-1.15)0.24
75-791.23 (1.12-1.34)< 0.011.21 (1.10-1.32)< 0.01
80-841.52 (1.37-1.69)< 0.011.48 (1.33-1.65)< 0.01
≥ 851.96 (1.70-2.26)< 0.011.92 (1.67-2.21)< 0.01
Race
White1.001.00
African American1.11 (0.95-1.29)0.181.13 (0.97-1.32)0.12
Other0.90 (0.78-1.05)0.170.88 (0.75-1.02)0.09
Year of diagnosis
1993-19971.27 (1.17-1.38)< 0.011.24 (1.14-1.35)< 0.01
1998-20021.18 (1.09-1.27)< 0.011.17 (1.08-1.27)< 0.01
2003-20061.001.00
Treatment stage
IA/IB0.20 (0.18-0.23)< 0.010.17 (0.15-0.20)< 0.01
IC/II0.35 (0.32-0.40)< 0.010.36 (0.32-0.40)< 0.01
IIIA/IIIB0.61 (0.53-0.71)< 0.010.62 (0.54-0.71)< 0.01
IIIC/IV1.001.00
Charlson-Klabunde comorbidity score
01.001.00
11.28 (1.18-1.38)< 0.011.26 (1.17-1.36)< 0.01
21.38 (1.22-1.56)< 0.011.37 (1.21-1.55)< 0.01
31.64 (1.34-2.00)< 0.011.64 (1.34-2.01)< 0.01
≥ 42.33 (1.73-3.15)< 0.012.27 (1.67-3.09)< 0.01
Histology
Serous1.001.00
Endometrioid0.76 (0.68-0.85)< 0.010.75 (0.68-0.84)< 0.01
Mucinous1.22 (1.06-1.41)< 0.011.22 (1.06-1.41)< 0.01
Clear cell0.83 (0.69-1.00)0.050.83 (0.69-1.00)0.05
Transitional0.79 (0.47-1.31)0.360.79 (0.48-1.32)0.37
Adenocarcinoma (NOS)1.07 (0.98-1.18)0.141.07 (0.97-1.17)0.2
Other1.02 (0.82-1.28)0.851.02 (0.82-1.28)0.85
Marital status
Married1.001.00
Not Married1.07 (1.00-1.14)0.051.07 (1.00-1.14)0.05
Unknown1.00 (0.82-1.23)0.970.99 (0.80-1.21)0.89
Surgeon specialty3
Non-GO1.001.00
GO0.90 (0.84-0.96)< 0.010.90 (0.84-0.97)< 0.01
Chemotherapy specialty3
Non-GO41.00
GO40.98 (0.89-1.08)0.68
Did not receive chemotherapy41.33 (1.19-1.47)< 0.01