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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Feb 10, 2016; 5(1): 28-38
Published online Feb 10, 2016. doi: 10.5317/wjog.v5.i1.28
MicroRNAs: New players in endometriosis
Josep Marí-Alexandre, Moisés Barceló-Molina, María Olcina-Guillem, Javier García-Oms, Aitana Braza-Boïls, Juan Gilabert-Estellés
Josep Marí-Alexandre, Moisés Barceló-Molina, María Olcina-Guillem, Aitana Braza-Boïls, Grupo de Hemostasia, Trombosis, Aterosclerosis y Biología Vascular, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain
Javier García-Oms, Juan Gilabert-Estellés, Área Maternoinfantil, Hospital General Universitario, 46014 Valencia, Spain
Juan Gilabert-Estellés, University of Valencia, 46010 Valencia, Spain
Author contributions: Marí-Alexandre J, Barceló-Molina M, Olcina-Guillem M and García-Oms J have performed the literature review and helped in the elaboration of the manuscript; Marí-Alexandre J, Braza-Boïls A and Gilabert-Estellés J have written and supervised the final version of the manuscript.
Supported by ISCIII and FEDER, Nos. PI011/00091, PI011/00566, PI14/01309, PI14/00253 and FI12/00012; RIC, Nos. RD12/0042/0029 and RD12/0042/0050; IIS La Fe 2011-211; Prometeo, No. 2011/027; and Sara Borrell Contract, No. CD13/0005.
Conflict-of-interest statement: Authors have no conflict of interest for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Juan Gilabert-Estellés, MD, PhD, Professor of Medicine, Chief of the Área Maternoinfantil, Hospital General Universitario, Av. Tres Cruces 2, 46014 Valencia, Spain. gilabert_juaest@gva.es
Telephone: +34-63-8064295 Fax: +34-96-1972014
Received: July 29, 2015
Peer-review started: August 6, 2015
First decision: September 16, 2015
Revised: December 2, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: February 10, 2016
Core Tip

Core tip: Endometriosis is an estrogen-dependent inflammatory disorder that limits the quality of life of affected women. Nowadays, a unifying theory regarding its exact etiopathogenic mechanism has not been achieved yet. Our objective is to review the current literature to better understand the role of microRNAs, one of the epigenetic players, in the pathophisiology of endometriosis and their potential as novel diagnostic biomarkers to guide therapeutic interventions in endometriosis.