Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Hematol. Aug 6, 2014; 3(3): 71-84
Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.71
Table 2 Diagnostic guidelines for hemophagocytic lymphohistiocytosis[38]
The diagnosis of HLH can be established if one of either (1) or (2) below is fulfilled
(1) A molecular diagnosis consistent with HLH
(2) Clinical diagnostic criteria fulfilled for 5 out of the 8 criteria below
Clinical criteria1 fever
2 splenomegaly
Routine laboratory criteria3 bicytopenia (Hb < 90 g/L,
platelets < 100 × 109/L, neutrophils < 1.0 × 109/L)
4 Hypertriglyceridemia (> 3.0 mmol/L)
and/or hypofibrinogenemia (< 1.5 g/L)
Specific histopathological/marker criteria5 hemophagocytosis
6 low or absent NK cell activity
7 hyperferritinemia (> 500 μg/L)
8 hyper-sIL-2R-nemia (> 2400 U/mL)