PVSG and WHO vs European Clinical, Molecular and Pathological Criteria for prefibrotic myeloproliferative neoplasms

Figure 10 Essential thrombocythemia case diagnosed in 1995 as chronic megakaryocytic granulocytic myelosis, and as JAK2 wild type primary megakaryocytic granulocytic myeloproliferation in 2006 (Figure 8) was complicated by slight anemia and increased bundles of reticulin fibrosis grade 2 after 10 years of hydroxurea treatment (Figure 9). A-C: Bone marrow histology findings in 2006 show thightly clustered immature megakaryocytes with low degree of dysmegakaryopoiesis and cloud-like nuclei. Sometimes the nuclei have an irregular contour and no real hyperchromasia; D: Increase in reticulin fibrosis with many cross-sections grade 2/myelofibrosis grade 1 (Table 5).