Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts

Figure 4 Targeting phase. Negative regulation of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) is indicated by blue lines and activation of its targets, shown in boxes, is indicated by red arrows. RANK: Receptor activator of nuclear factor-κB; ITAM: Immunoreceptor tyrosine-based activation motif; OSCAR: Osteoclast-associated receptor; Blimp1: B-lymphocyte-induced maturation protein-1; DC-STAMP: Dendritic cell-specific transmembrane protein; TRAP: Tartrate-resistant acid phosphatase; IRF-8: Interferon regulatory factor-8; MafB: V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B; Bcl6: B cell lymphoma 6; CLC: Chloride channel.