Diagnosis and management of neuropathic pain post-total knee replacement: A systematic review

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-analyses flow diagram. The Bertram et al’s paper[33] relating to the steroidogenic acute regulatory protein pathway was excluded from our review as it did not relate specifically to neuropathic pain post total knee replacement. While it did use Neuropathic Pain Scores such as Douleur-Neuropathique-4 and PainDETECT, the data that was collected only included mean values and was not used to classify or delineate patients with neuropathic pain within their cohort. The change in PainDETECT scores was similar and did not change between one and four years. Their study did not show a significant difference in the mean PainDETECT scores during follow up. Chapman et al[27] was excluded as it related to primarily nociceptive pain and was not specific to post-total knee replacement. TKR: Total knee replacement; OA: Osteoarthritis.