Eosinophilic gastroenteritis: Approach to diagnosis and management

Table 3 Published cases of eosinophilic gastroenteritis treated with montelukast

Ref.	Patient no.	Intestinal layer	Location	Previous treatment	Response
Neustrom et al[63], 1999	1	Mucosal	Esophagus + stomach + small intestine	Failure of response to elimination diet, cromolyn sodium, ranitidine and hydroxyzine	Clinical and histologic response (+)
Schwartz et al[64], 2001	1	Serosal	Duodenum	Steroid dependent	Remission (+) over 4 wk
Lu et al[65], 2003	2	Mucosal	-	Steroid dependent	1 → Not effective
					2 → Partial response with tapering of prednisone to 10 mg/d
Vanderhoof et al[66], 2003	8	Mucosal	Esophagus (n = 4) Duodenum (n = 2) Colon (n = 2)	Failure of standard therapies	Clinical response (+) within 1 mo
Copeland et al[9], 2004	1	Mucosal	Stomach	Steroid refractory EGE (also receiving 6MP and 5ASA for UC)	Not effective
Friesen et al[67], 2004	40	Mucosal	Duodenum	None	Response (+) within 2 wk
Quack et al[68], 2005	1	Serosal	Ileum	Steroid dependent	Remission (+) over 2 yr
Urek et al[21], 2006	1	Serosal	Ileum	Steroid dependent	Response (+) within 4 wk
De Maeyer et al[69], 2011	1	-	-	Steroid dependent	Response (+)
Tien et al[5], 2011	12	Mucosal	Stomach + duodenum + colon + esophagus	4 → None 8 → Steroid dependent	Remission (+) over 12 mo 4/8 → Successful steroid tapering 3/8 → Not effective 1/8 → Lost to follow-up
Selva Kumar et al[70], 2011	1	Mucosal	Small intestine	Unresponsive to standard therapy	Response (+)
Müller et al[26], 2014	2	Mucosal (+/- serosal or muscular)	Stomach + small intestine	1 and 2 → Steroid dependent	1 → Remission (+) in combination with low-dose prednisone 2 → Remission (+) (off steroids)
Wong et al[15], 2015	2	Mucosal (+/- serosal or muscular)	-	1: Steroid dependent 2: None	Remission (+) for 36 mo (in combination with prednisone) Asymptomatic for 10 mo

5ASA: 5-Aminosalicylic acid; 6MP: 6 Mercaptopurine; UC: Ulcerative colitis.