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World J Gastrointest Pharmacol Ther. Nov 6, 2013; 4(4): 113-119
Published online Nov 6, 2013. doi: 10.4292/wjgpt.v4.i4.113
Published online Nov 6, 2013. doi: 10.4292/wjgpt.v4.i4.113
Validation of methods to assess potential biomarkers in pediatric patients with esophageal eosinophilia
Jennifer M Colombo, Nancy A Neilan, Craig A Friesen, Divisions of Gastroenterology, Children’s Mercy Hospital and Clinics, University of Missouri at Kansas City School of Medicine, Kansas City, MO 64108, United States
Jennifer Verrill Schurman, Developmental and Behavioral Sciences, Children’s Mercy Hospital and Clinics, University of Missouri at Kansas City School of Medicine, Kansas City, MO 64108, United States
Author contributions: Colombo JM, Schurman JV and Friesen CA designed the research; Colombo JM and Neilan NA performed the research; Colombo JM, Schurman JV and Friesen CA analyzed the data; Colombo JM, Neilan NA, Schurman JV and Friesen CA participated in the drafting and editing of the manuscript; all authors approved of the final version to be published.
Correspondence to: Jennifer M Colombo, MD, Divisions of Gastroenterology, Children’s Mercy Hospital and Clinics, University of Missouri at Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, United States. jmcolombo@cmh.edu
Telephone: +1-816-2343016 Fax: +1-816-8551721
Received: June 13, 2013
Revised: August 9, 2013
Accepted: September 4, 2013
Published online: November 6, 2013
Revised: August 9, 2013
Accepted: September 4, 2013
Published online: November 6, 2013
Core Tip
Core tip: Esophageal mucosal eosinophilia challenges many clinicians and researchers. Biomarkers have been proposed to help clarify and better characterize eosinophil driven disease. This study provides validation of methods used previously to differentiate low eosinophil density from high eosinophil density. Eosinophilic major basic protein appears to be the best predictor for classification of eosinophilia at both extremes. This lays the ground work for future studies to examine varying degrees of eosinophilia using biomarkers.