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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. May 6, 2016; 7(2): 171-178
Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.171
Non-pharmacological treatment of Helicobacter pylori
Haim Shmuely, Noam Domniz, Jacob Yahav
Haim Shmuely, Jacob Yahav, Department Medicine D, Kaplan Medical Center, Rehovot 76100, Israel
Noam Domniz, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52506, Israel
Author contributions: Shmuely H, Domniz N and Yahav J contributed equally to this work.
Conflict-of-interest statement: The authors have no conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Haim Shmuely, MD, Head, Department Medicine D, Kaplan Medical Center, Pasternak St., Rehovot 76100, Israel. hshmuely@zahav.net.il
Telephone: +972-8-9441996 Fax: +972-8-9441866
Received: April 28, 2015
Peer-review started: May 6, 2015
First decision: September 8, 2015
Revised: January 13, 2016
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: May 6, 2016
Processing time: 358 Days and 1.9 Hours
Abstract

Many food and plant extracts have shown in vitro anti-Helicobacter pylori (H. pylori) activity, but are less effective in vivo. The anti-H. pylori effects of these extracts are mainly permeabilitization of the membrane, anti-adhesion, inhibition of bacterial enzymes and bacterial grown. We, herein, review treatment effects of cranberry, garlic, curcumin, ginger and pistacia gum against H. pylori in both in vitro, animal studies and in vivo studies.

Keywords: Helicobacter pylori; Cranberry; Garlic; Curcumin; Ginger; Pistacia gum

Core tip: Helicobacter pylori (H. pylori) infection is difficult to eradicate and therefore, it is necessary to combine several antibiotics as well as administering a proton-pump inhibitor. Many food and plant extracts have demonstrated in vitro antibacterial activity, however, in in vivo, they are less effective. The food reviewed, herein, can be effective in preventing and/or reducing H. pylori infection. A preventive dietary approach can be very inexpensive in areas with poor health care systems.