Efficacy and tolerability of hydrogen carbonate-rich water for heartburn

Table 1 Components of the test mineral water

Cations	Content(mg/L)	Anions	Content(mg/L)
Lithium	0.14	Fluoride	0.15
Sodium	121.0	Chloride	39.0
Potassium	10.2	Bromide	0.11
Rubidium	0.01	Iodide	0.019
Magnesium	109.4	Nitrate	8.28
Calcium	331.0	Sulphate	34.8
Strontium	2.54	Hydrogen phosphate	0.1
Barium	0.055	Hydrogen carbonate	1775.0
Chromium	0.005	Undissociated substances
Manganese	0.03	Metasilicic acid	37.2
Iron	0.068	Metaboric acid	1.1
Nickel	0.002	Metatitanic acid	0.002
Copper	0.002	Gaseous substances
Silver	0.002	Free dissolved carbon dioxide	3500
Zinc	0.007
Aluminium	0.004
Lead	0.005

Table 2 Overview of the changes with regard to heartburn (full analysis set)

Heartburn (n = 48)	V2mean (SD)median	V5mean (SD)median	V2-V5mean (SD)median	P value	Proportion of patients displaying a decrease/an increase	P value
Frequency	8.06 (4.43)	3.00 (2.29)	5.06 (4.81)	< 0.001	89.6%/8.3%	< 0.001
	8.0	2.5	5.0
Duration (min)	43.7 (55.9)	24.7 (32.2)	19.0 (40.7)	0.002	79.2%/20.8%	< 0.001
	24.5	12.7	4.2