Review
Copyright ©The Author(s) 2016.
World J Gastrointest Pathophysiol. May 15, 2016; 7(2): 199-210
Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.199
Table 1 Summary of the role of Hedgehog signaling in pancreatitis, indicating the protective role in acute pancreatitis vs disease-progressive function in chronic pancreatitis as well the possible association to pancreatic cancerogenesis[32-38,42,43]
Acute pancreatitisChronic pancreatitis
Pathogenetic effect of Hh Protective Progressive
Detected members of Hh ↑Shh (Ihh, Dhh), Gli1 ↑Ihh (Shh), Ptc, Hip, SMO, Gli1, Gli2
Interactive cells (auto-and paracrine effects) Acinar/ductal cells with; acute inflammatory cells Acinar/ductal cells with; PSC
(Immune) mediators of inflammation IL-10, IL-6, mIL-8, Mcp-1, and M-csf (Csf1) MT1-MMP, MMP9, TGF-β1, smooth muscle actin, fibronectin 1, type I collagen
Association to cancerogenesis No Yes, possibly via ADM and PanIn
Hh: Hedgehog; Shh: Sonic Hh; Ihh: Indian Hh; Dhh: Desert hedgehog; IL: Interleukin; mIL-8: Murine homolog of IL8; Mcp-1: Monocyte chemoattractant protein-1; M-csf: Macrophage colony-stimulating factor; Ptc: Patched; Hip: Hh-interacting protein; SMO: Smoothened; MT1-MMP: Membrane-type 1 matrix metalloproteinase; MMP-9: Matrix metallopeptidase 9; TGF-β: Transforming growth factor beta; ADM: Acino-ductal metaplasia; PanIn: Pancreatic intraductal neoplasia; PSC: Pancreatic stellate cells.