Review
Copyright ©The Author(s) 2021.
World J Gastrointest Pathophysiol. Jul 22, 2021; 12(4): 59-83
Published online Jul 22, 2021. doi: 10.4291/wjgp.v12.i4.59
Table 2 Cellular micro ribonucleic acids deregulated during human immunodeficiency virus infection
Sample type
miRNAs deregulated
Ref.      
PBMCs from HIV-infected patients↑ miR-9; ↓ miR-29c, miR-31, miR-125b, miR-146b-5p, miR-150, Let-7g[181]
T cells from HIV-infected individuals↓ miR-16, miR-146b, miR-150, miR-223[182]
HIV-1 infected PBMCs↑ miR-223; ↓ miR-21, miR-26a, miR-29a, miR-29b, miR-29c, miR-155[183]
HIV-1 infected PBMCs↑ miR-3195, miR-3656, miR-4492, and miR-6087; ↓ miR-1273h-3p, miR-1273h-5p, miR-671-5p, and miR-7-5p[118]
HIV-2-infected PBMCs↑ miR-18a-3p and hsa-miR-320b[118]
HIV-2-infected MDMs↑ miR-542-3p, miR-375, miR-195-5p, miR-30c-2-3p, miR-4802-3p, and miR-26b-5p[118]
HIV-1- and HIV-2-infected MDMs↓ miR-148b-5p, hsa-miR-26a-2-3p, miR-199a-1, miR-199a-2, and miR-874-5p [118]
HIV-1-transfected HeLa cells↓ miR-16, miR-93, miR-148b, miR-221[184]
HIV-1 infected Jurkat cells.↑ miR-122, miR-297, miR-370, and miR-373; ↓ miR-17-5p and miR-20a[185]
latently infected CD4+ T cells↑ miR-196b and miR-1290[186]
PBMCs obtained from HIV-1 positive individuals with high viral load↑ miR19b, miR-34a, miR-144, miR-146a, miR-155, miR-382, miR-615-3p[187]
Plasma obtained from patients with HIV infection ↓ miR-3162-3p[188]
HIV-1-infected HUT78 cells and CD4+ T cells from chronic HIV-1 infected individuals ↓ Let-7 miRs[189]
HIV-1 positive plasma samples in the acute stage infection↑ miR-16-5p, miR-20b-5p, miR-24-3p, miR-142-5p, miR-195-5p, miR-206, miR-223-3p, miR-885-5p, and let-7 g-3p; ↓ miR-34c-3p, miR-181c-3p, miR-202-3p, and miR-409-3p[190]
HIV-1 infected CD4+ T cells↓ miR-20a and miR-106b[191]
↑: Upregulation; ↓: Downregulation; miRNAs: Micro ribonucleic acid; HIV: Human Immunodeficiency virus; PBMC: Peripheral blood mononuclear cells; MDM: Monocyte-derived macrophages.