Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula

doi:10.4291/wjgp.v10.i4.42

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 13, 2019; 10(4): 42-53
Published online Nov 13, 2019. doi: 10.4291/wjgp.v10.i4.42

Table 1 Clinical features

	Idiopathic	Crohn’s Disease	P value
Mean PDAI (SD)	5.67 (2.76)	8.07 (3.99)	0.01^a
Mean EQ VAS (SD)	71.2 (21.1)	63.4 (20.2)	0.22
Mean EQ index (SD)	0.734 (0.259)	0.715 (0.214)	0.80
Seton in situ, n (%)	21 (44)	3 (23)	0.22
Number of fistulae, n (%)			0.09
Single unbranched	31 (65)	3 (23)
Single branched	15 (31)	7 (54)
Multiple	2 (4)	3 (23)
Parks’ classification, n (%)			0.54
Inter-sphincteric	7 (15)	1 (8)
Trans-sphincteric	38 (79)	10 (77)
Supra-sphincteric	3 (6)	2 (15)
High primary tract	15 (31)	6 (46)	0.34
Secondary tract(s), n (%)			0.02^a
None	31 (65)	4 (31)
Infralevator	14 (29)	5 (38)
Supralevator	3 (6)	4 (31)
Horseshoe, n (%) extension(s)	12 (25)	5 (38)	0.49
Collection(s) , n (%)	16 (33)	12 (92)	< 0.001^a
Thickened rectum, n (%)	1 (2)	7 (54)	< 0.001^a

Perineal Disease Activity Index, EuroQoL visual analogue score and index measured at pre-operative clinic assessment. Continuous data was compared using t-test. Discrete data compared using Fisher’s Exact test. P < 0.05 was considered significant.

^aP < 0.05. PDAI: Perineal Disease Activity Index; SD: Standard deviation; EQ: EuroQol; VAS: Visual analogue score.

Citation: Haddow JB, Musbahi O, MacDonald TT, Knowles CH. Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula. World J Gastrointest Pathophysiol 2019; 10(4): 42-53
URL: https://www.wjgnet.com/2150-5330/full/v10/i4/42.htm
DOI: https://dx.doi.org/10.4291/wjgp.v10.i4.42