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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Aug 15, 2015; 6(3): 51-57
Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.51
Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.51
Gut region-dependent alterations of nitrergic myenteric neurons after chronic alcohol consumption
Mária Bagyánszki, Nikolett Bódi, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 6726 Szeged, Hungary
Author contributions: Both of the authors contributed to this paper.
Supported by The János Bolyai Research Scholarship of the Hungarian Academy of Sciences (Mária Bagyánszki); by the Hungarian Scientific Research Fund, OTKA grant PD 108309 (Nikolett Bódi).
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mária Bagyánszki, PhD, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, 6726 Szeged, Hungary. bmarcsi@bio.u-szeged.hu
Telephone: +36-62-343103 Fax: +36-62-544149
Received: January 28, 2015
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: March 27, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: August 15, 2015
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: March 27, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: August 15, 2015
Core Tip
Core tip: Chronic ethanol administration causes neurodegeneration in the central nervous system. In the enteric nervous system neurodegeneration was not demonstrated, however alcohol-induced quantitative, functional and neurochemical changes of nitrergic myenteric neurons were observed in gut region-dependent way. These suggest that disturbed gastrointestinal transit characteristic to alcoholic patients due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis. The better understanding of the effects of chronic ethanol administration on enteric neurons may reveal new targets for therapy.