Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine

Figure 10 4’-[methyl-¹¹C]-thiothymidine images in clear cell renal carcinoma. A 78-year-old male with a clear cell renal carcinoma (RCC) in the right kidney. Contrast-enhanced abdominal CT (A), fused ¹¹C-4DST PET/CT (axial image) (B), fused ¹⁸F-FDG PET/CT (axial image) (C), coronal ¹¹C-4DST PET (D), and coronal ¹⁸F-FDG PET (E) images are shown. The uptake of ¹¹C-4DST was predominantly near the outer surface of the RCC tumor; the uptake of ¹⁸F-FDG was more diffuse. Reprinted from Minamimoto et al[25], with the permission of Springer. ¹¹C-4DST: 4’-[methyl-¹¹C]-thiothymidine; ¹⁸F-FDG: 2-Deoxy-2-[¹⁸F]fluoro-D-glucose; PET: Positron emission tomography; CT: Computed tomography.