Impact of the arterial input function on microvascularization parameter measurements using dynamic contrast-enhanced ultrasonography

Table 2 In vitro and in vivo experiments: Statistical analyses

	In vitro results		In vivo results
	Repositioning of the probe: Fisher’s test P values	Variation of the flow rate: ANOVA P values	Multiple injections: ANOVA P values	Day of examination: ANOVA P values
Semi-quantitative microvascularization parameters
PI	0.077	< 0.001	0.080	< 0.001
TPI	0.302	0.004	0.595	0.641
Slope of the WI	0.059	0.006	0.141	< 0.001
MTT	0.562	< 0.001	0.885	0.016
AUC	0.731	< 0.001	0.073	0.01
AUWI	0.276	0.024	0.060	0.001
AUWO	0.860	0.006	0.078	0.016
Quantitative microvascularization parameters
BF	0.055	0.004	0.071	0.116
BV	0.063	0.053	0.429	0.015
MTT	0.131	0.649	0.126	0.645

ANOVA: Analysis of variance; PI: Peak intensity; T_PI: Time to peak intensity; WI: The wash-in; MTT: The mean transit time; AUC: The area under the curve; AUWI: The area under the wash-in; AUWO: The area under the wash-out; BF: The tissue blood flow; BV: The tissue blood volume.