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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2016; 8(11): 880-886
Published online Nov 28, 2016. doi: 10.4329/wjr.v8.i11.880
Published online Nov 28, 2016. doi: 10.4329/wjr.v8.i11.880
Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer
Kenji Kawada, Masayoshi Iwamoto, Yoshiharu Sakai, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Author contributions: Kawada K wrote the paper; Iwamoto M and Sakai Y contributed critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: The authors have no conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kenji Kawada, MD, PhD, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin- Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. kkawada@kuhp.kyoto-u.ac.jp
Telephone: +81-75-3667595 Fax: +81-75-3667642
Received: June 1, 2016
Peer-review started: June 9, 2016
First decision: July 30, 2016
Revised: August 24, 2016
Accepted: September 13, 2016
Article in press: September 15, 2016
Published online: November 28, 2016
Peer-review started: June 9, 2016
First decision: July 30, 2016
Revised: August 24, 2016
Accepted: September 13, 2016
Article in press: September 15, 2016
Published online: November 28, 2016
Core Tip
Core tip: Malignant cancers are preferential to metabolize glucose by glycolysis, even in the presence of oxygen, so-called Warburg effect. This elevated glucose metabolism is responsible for 18F-fluorodeoxyglucose (FDG) accumulation into cancer cells, which results in the positive signals in FDG-positron emission tomography scans. In spite of its clinical utility, the cellular and molecular mechanisms of 18F-FDG accumulation have not yet been elucidated. Here we review the current literature published with respect to the mechanisms of 18F-FDG accumulation into colorectal cancer tissues.