Di Perri C, Thibaut A, Heine L, Soddu A, Demertzi A, Laureys S. Measuring consciousness in coma and related states. World J Radiol 2014; 6(8): 589-597 [PMID: 25170396 DOI: 10.4329/wjr.v6.i8.589]
Corresponding Author of This Article
Carol Di Perri, MD, Cyclotron Research Center and Neurology Department, Coma Science Group, University of Liège, Allée du 6 août 8, Sart Tilman B30, 4000 Liège, Belgium. caroldiperri@hotmail.com
Research Domain of This Article
Neuroimaging
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Aug 28, 2014; 6(8): 589-597 Published online Aug 28, 2014. doi: 10.4329/wjr.v6.i8.589
Measuring consciousness in coma and related states
Carol Di Perri, Aurore Thibaut, Lizette Heine, Andrea Soddu, Athena Demertzi, Steven Laureys
Carol Di Perri, Neuroradiology, National Neurological Institute C Mondino, 27100 Pavia, Italy
Carol Di Perri, Aurore Thibaut, Lizette Heine, Athena Demertzi, Steven Laureys, Cyclotron Research Center and Neurology Department, Coma Science Group, University of Liège, 4000 Liège, Belgium
Andrea Soddu, Brain and Mind Institute, Physics and Astronomy Department, Western University, London, Ontario, N6A 3K7, Canada
Author contributions: Di Perri C designed and wrote the manuscript; Thibaut A, Heine L, Soddu A and Demertzi A were involved in designing and editing the manuscript; Laureys S supervised the manuscript design and writing; all authors were involved in literature search.
Supported by The European Commission; the James McDonnell Foundation; the European Space Agency; Mind Science Foundation; the French Speaking Community Concerted Research Action; the Belgian interuniversity attraction pole; the Public Utility Foundation “Université Européenne du Travail”; “Fondazione Europea di Ricerca Biomedica” and the University and University Hospital of Liège
Correspondence to: Carol Di Perri, MD, Cyclotron Research Center and Neurology Department, Coma Science Group, University of Liège, Allée du 6 août 8, Sart Tilman B30, 4000 Liège, Belgium. caroldiperri@hotmail.com
Telephone: +32-43-662316 Fax: +32-43-662946
Received: February 28, 2014 Revised: May 9, 2014 Accepted: June 14, 2014 Published online: August 28, 2014
Abstract
Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Severe acquired brain injuries resulting in a disorder of consciousness (DOC) provide a model from which insights into consciousness can be drawn. A number of recent studies highlight the difficulty in making a diagnosis in patients with DOC based only on behavioral assessments. Here we aim to provide an overview of how neuroimaging techniques can help assess patients with DOC. Such techniques are expected to facilitate a more accurate understanding of brain function in states of unconsciousness and to improve the evaluation of the patient’s cognitive abilities by providing both diagnostic and prognostic indicators.
Core tip: In this review we show the main ways neuroimaging techniques contribute to both understanding the neural correlates of consciousness and detecting possible consciousness residual in severly traumatic brain injured patients. In particular, we make reference to the latest research in terms of both improving the diagnosis of patients with disorder of consciousness, and understanding the brain processes underlining consciousness, such as a broad and more complex than previously thought alteration of brain connectivity architecture.
