Sporea I, Şirli R, Bota S, Fierbinţeanu-Braticevici C, Petrişor A, Badea R, Lupşor M, Popescu A, Dănilă M. Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis? World J Radiol 2011; 3(7): 188-193 [PMID: 21860715 DOI: 10.4329/wjr.v3.i7.188]
Corresponding Author of This Article
Dr. Ioan Sporea, Professor, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 10 Iosif Bulbuca Bv., 300736 Timisoara, Romania. isporea@umft.ro
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World J Radiol. Jul 28, 2011; 3(7): 188-193 Published online Jul 28, 2011. doi: 10.4329/wjr.v3.i7.188
Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?
Ioan Sporea, Roxana Şirli, Simona Bota, Carmen Fierbinţeanu-Braticevici, Ana Petrişor, Radu Badea, Monica Lupşor, Alina Popescu, Mirela Dănilă
Ioan Sporea, Roxana Şirli, Simona Bota, Alina Popescu, Mirela Dănilă, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 10 Iosif Bulbuca Bv., 300736 Timisoara, Romania
Carmen Fierbinţeanu-Braticevici, Ana Petrişor, IInd Medical Clinic and Gastroenterology, University Hospital, 169 Independenţei Avenue, Sector 5, 050098 Bucharest, Romania
Radu Badea, Monica Lupşor, Department of Medical Imaging, 3rd Medical Clinic, University of Medicine and Pharmacy, Cluj-Napoca, 21-23 Croitorilor Str., 400162, Cluj-Napoca, Romania
Author contributions: Sporea I wrote the paper, designed and supervised the study; Sporea I, Fierbinţeanu-Braticevici C and Badea R supervised the study; Şirli R, Popescu A, Bota S, Petrişor A, Lupşor M and Dănilă M performed the research; Bota S and Şirli R analyzed the data; Şirli R revised the manuscript.
Correspondence to: Dr. Ioan Sporea, Professor, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 10 Iosif Bulbuca Bv., 300736 Timisoara, Romania. isporea@umft.ro
Telephone: +40-256-309455 Fax: +40-256-300488
Received: March 26, 2011 Revised: May 25, 2011 Accepted: May 9, 2011 Published online: July 28, 2011
Abstract
AIM: To determine whether acoustic radiation force impulse (ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus (HCV) hepatitis.
METHODS: We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy (LB). In each patient we performed LB (evaluated according to the Metavir score) and ARFI measurements (using a Siemens Acuson S2000™ ultrasound system: 10 valid measurements were performed and median values were calculated and expressed in meters/second (m/s).
RESULTS: A direct, strong, correlation (Spearman r = 0.707) was found between ARFI measurements and fibrosis (P < 0.0001). For predicting the presence of fibrosis (F ≥ 1 Metavir), significant fibrosis (F ≥ 2), severe fibrosis (F ≥ 3) and cirrhosis (F = 4), the cut-off values of 1.19, 1.21, 1.58 and 1.82 m/s were determined, respectively, liver stiffness measurements had 73%, 84%, 84% and 91% Se respectively; 93%, 91%, 94%, 90% Sp, respectively; with AUROCs of 0.880, 0.893, 0.908 and 0.937, respectively.
CONCLUSION: ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV patients
