Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease

Figure 4 Schematic diagram representing the mechanism of action of liver X receptor-α. A: Wild type functional liver X receptor-α (LXR-α) in healthy controls; B: Mutant non-functional LXR-α in coronary heart disease patients; C: Mutated but functional (to some extent) LXR-α when rescued by Vitamin D₃. BRCA1: Breast and ovarian cancer susceptibility 1; BARD1: BRCA1-associated RING domain 1; LXRE: liver X receptor.