Next generation sequencing in cardiovascular diseases

Table 1 Next generation sequencing approaches in cardiovascular diseases

	Disease	NGS approach	Ref.
Monogenic diseases	DCM	Target re-sequencing in 47 associated genes	Meder et al[24]
		Sequencing of TTN gene	Herman et al[27]
	HCM	Target re-sequencing in 47 associated genes	Meder et al[24]
		Target re-sequencing in 16 associated genes	Dames et al[25]
		RNA sequencing	Matkovich et al[28]
	Mitochondrial cardiomyopathies	Mitochondrial DNA sequencing	Zaragoza et al[26]
	Channelopathies	No approach
Complex diseases	CAD	Target re-sequencing of 9p21.3 region	Shea et al[47]
		Sequencing of ADIPOQ gene	Bowden et al[49]
	AA	Target sequencing in associated genes	Harakalova et al[50], Sakai et al[52]
	Thrombophilia	Target sequencing in gene associated	Dewey et al[53]

DCM: Dilated Cardiomyopathies; HCM: Hypertrophic cardiomyopathies; CAD: Coronary artery disease; AA: Aortic aneurysm; NGS: Next generation sequencing; TTN: Titin; ADIPOQ: Adiponectin.