Hydrogen alleviates right ventricular hypertrophy by inhibiting ferroptosis via restoration of the Nrf2/HO-1 signaling pathway

Figure 10  Hydrogen alleviates ferroptosis by inhibiting the Nrf2/HO-1 pathway in an angiotensin II-treated H9C2 cells. A: Representative western blotting of Nrf2, TFR1, SLC7A11, HO-1, FTH1, and GPX4 proteins; B: Relative protein levels of Nrf2, TFR1, SLC7A11, HO-1, FTH1, and GPX4. Data are expressed as the mean ± SD; n ≥ 3. ^aP < 0.05 and ^cP < 0.01: Ang II group vs control group; ^bP < 0.05 and ^dP < 0.01: Ang II+H₂ group vs Ang II group. MCT: Monocrotaline; H₂: Hydrogen; Ang II: An angiotensin II.