Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway

Figure 6 Doxorubicin influenced mitochondrial dynamics related proteins. A: Protein levels of calumenin, optic atrophy 1 and dynamin-related protein 1 were measured by western blotting; B: Protein levels of calumenin; C: Protein levels of optic atrophy 1; D: Protein levels of dynamin-related protein 1. Data are expressed as mean ± SD, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs control (n = 6) and (n = 3). DOX: Doxorubicin; CON: Control; OPA-1: Optic atrophy 1; DRP-1: Dynamin-related protein 1.