Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway

doi:10.4330/wjc.v17.i5.104839

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May 26, 2025 (publication date) through May 26, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. May 26, 2025; 17(5): 104839
Published online May 26, 2025. doi: 10.4330/wjc.v17.i5.104839

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Figure 1 Doxorubicin induced changes. A: Doxorubicin induced changes in body weight; B: Doxorubicin induced changes in heart weight of rats in each group; C: Doxorubicin caused pathological damage in the myocardium; D: Doxorubicin caused changes in collagen fibrosis rate. The results of Masson staining were observed under a microscope (40 ×) (n = 6). Data are expressed as mean ± SD, ^bP < 0.01, ^cP < 0.001 vs control group (n = 6). DOX: Doxorubicin; CON: Control.

Citation: Shi H, Yang SA, Bai LY, Du JJ, Wu Z, He ZH, Liu H, Cui JY, Zhao M. Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway. World J Cardiol 2025; 17(5): 104839
URL: https://www.wjgnet.com/1949-8462/full/v17/i5/104839.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i5.104839