Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway

doi:10.4330/wjc.v17.i5.104839

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May 26, 2025 (publication date) through May 26, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. May 26, 2025; 17(5): 104839
Published online May 26, 2025. doi: 10.4330/wjc.v17.i5.104839

Table 1 The concentration of intracellular free Ca²⁺ of cardiomyocytes in vivo

Group	The concentration of intracellular free Ca²⁺ (nmol/L)
CON	18.62 ± 3.21 (nmol/L)
2 weeks DOX	56.45 ± 11.3 (nmol/L)^b
4 weeks DOX	87.61 ± 9.65 (nmol/L)^c
8 weeks DOX	101.21 ± 10.14 (nmol/L)^c

^cP < 0.001.

^bP < 0.01 vs CON (n = 6).

mean ± SD was analyzed. DOX: Doxorubicin; CON: Control.

Citation: Shi H, Yang SA, Bai LY, Du JJ, Wu Z, He ZH, Liu H, Cui JY, Zhao M. Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway. World J Cardiol 2025; 17(5): 104839
URL: https://www.wjgnet.com/1949-8462/full/v17/i5/104839.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i5.104839