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World J Cardiol. Apr 26, 2014; 6(4): 205-212
Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.205
Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.205
Prognostic value of increased carbohydrate antigen in patients with heart failure
Ana B Méndez, Andreu Ferrero, Mariana Noguero, Sònia Mirabet, Juan Cinca, Eulàlia Roig, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biomèdica Sant Pau and Universitat Autònoma, 08041 Barcelona, Spain
Jordi Ordoñez-Llanos, Teresa Mir, Josefina Mora, Biochemistry Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biomèdica Sant Pau and Universitat Autònoma, 08041 Barcelona, Spain
Antoni Bayes-Genis, Cardiology Department, Hospital Germans Trias I Pujol, 08916 Badalona, Spain
Author contributions: Mendez AB contributed to design of the study, analysis and interpretation of data, manuscript writing and final approval of manuscript; Ordoñez-Llanos J contributed to analysis of data, review of CA125 and NT-proBNP determinations and substantial contribution to manuscript review; Ferrero A contributed to statistical assessment and substantial contribution to manuscript review; Noguero M contributed to patient selection and follow-up, Serotec and analysis of data; Mir T and Mora J contributed to CA125 and NT-proBNP determinations, analysis of data, substantial contribution to manuscript; Bayes-Genis A and Mirabet S contributed to patient selection and follow-up, analysis of data, substantial contribution to manuscript; Cinca J contributed to design of the study and substantial contribution to manuscript review; Roig E contributed to design of the study, selection of patients, analysis of data, and substantial contribution to manuscript review.
Supported by Ministerio Español de Salud, Redes de Investigación del Instituto de Salud Carlos III (RIC, RD12/0042) y Fondo Europeo de Desarrollo Regional (FEDER)
Correspondence to: Eulàlia Roig, MD, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biomèdica Sant Pau and Universitat Autònoma, C/ Mas Casanovas 90, 08041 Barcelona, Spain. eroigm@santpau.cat
Telephone: +34-93-5565958 Fax: +34-93-5565604
Received: October 30, 2013
Revised: March 7, 2014
Accepted: March 13, 2014
Published online: April 26, 2014
Revised: March 7, 2014
Accepted: March 13, 2014
Published online: April 26, 2014
Core Tip
Core tip: Increased carbohydrate antigen 125 (CA125) has prognostic implications in acute heart failure (HF). The aim of this study was to assess the prognostic value of increased CA125 and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide (NT-proBNP) in stable HF patients. Higher CA125 values correlated with outcomes. The highest risk was observed when both biomarkers CA125 and NT-proBNP were elevated vs not elevated (HR = 8.95, 95%CI: 3.11-25.73; P < 0.001). CA125 > 60 KU/L identified patients in stable HF with very poor survival. Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes.