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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2021; 13(12): 733-744
Published online Dec 26, 2021. doi: 10.4330/wjc.v13.i12.733
Published online Dec 26, 2021. doi: 10.4330/wjc.v13.i12.733
Prognostic value of left atrial size in hypertensive African Americans undergoing stress echocardiography
Abhishek Khemka, Harvey Feigenbaum, Stephen G Sawada, Department of Medicine, Division of Cardiology, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis, IN 46202, United States
David A Sutter, Department of Cardiology, Michigan Heart, Ann Arbor, MI 48197, United States
Mazin N Habhab, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Athanasios Thomaides, Department of Cardiology, MedStar Health, Washington, DC 20007, United States
Kyle Hornsby, Department of Cardiology, Indiana University Health, Bloomington, IN 47403, United States
Author contributions: Khemka A, Sutter DA, Thomaides A and Hornsby K contributed to data collection; Khemka A, Sutter DA, Habhab M and Sawada SG contributed to data analysis; Khemka A, Habhab M and Sawada SG contributed to writing final manuscript; Sutter DA, Thomaides A, Hornsby K and Feigenbaum H contributed to manuscript review; Feigenbaum H contributed to study conception, design, supervision; Sawada SG contributed to study conception, design.
Institutional review board statement: In accordance with 45 CFR 46.101(b) and/or IU HRPP Policy, the above-referenced protocol is granted exemption. Exemption of this submission is based on your agreement to abide by the policies and procedures of the Indiana University Human Research Protection Program (HRPP) and does not replace any other approvals that may be required.
Informed consent statement: This was a retrospective study that the IRB deemed as exempt and so we did not need informed consent forms signed by patients.
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: The identified patient data are available upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abhishek Khemka, MD, Assistant Professor, Department of Medicine, Division of Cardiology, Indiana University School of Medicine, Krannert Institute of Cardiology, 1800 N Capitol Avenue Suite E371, Indianapolis, IN 46202, United States. akhemka@iu.edu
Received: March 25, 2021
Peer-review started: March 30, 2021
First decision: June 17, 2021
Revised: July 1, 2021
Accepted: November 24, 2021
Article in press: November 24, 2021
Published online: December 26, 2021
Peer-review started: March 30, 2021
First decision: June 17, 2021
Revised: July 1, 2021
Accepted: November 24, 2021
Article in press: November 24, 2021
Published online: December 26, 2021
Core Tip
Core Tip: In hypertensive African American patients referred for stress testing, left atrial (LA) enlargement was infrequent when using the established references values for the general population. Indexed LA Antero-posterior diameter has a superior area under the curve compared to LA diameter alone for discrimination of survivors and non-survivors. LA enlargement is an independent predictor of mortality on long-term follow-up when assessed as a continuous variable or when using a lower reference value derived from our population.