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World J Cardiol. Jun 26, 2010; 2(6): 160-162
Published online Jun 26, 2010. doi: 10.4330/wjc.v2.i6.160
Published online Jun 26, 2010. doi: 10.4330/wjc.v2.i6.160
Profound thrombocytopenia induced by clopidogrel with a prior history of long-term safe administration
Yuan-Lin Guo, Jian-Jun Li, Jin-Qing Yuan, Xue-Wen Qin, Xin Zheng, Chao-Wei Mu, Yi-Hong Hua, Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
Author contributions: GuoYL collected, prepared and presented the data; Li JJ analyzed and elucidated the data; Yuan JQ, Qin XW, Zheng X, Mu CW and Hua YH participated in preparing the data and the treatment of the patient.
Correspondence to: Dr. Jian-Jun Li, MD, PhD, Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China. lijnjn@yahoo.com.cn
Telephone: +86-10-88396077 Fax: +86-10-68331730
Received: May 4, 2010
Revised: May 24, 2010
Accepted: May 31, 2010
Published online: June 26, 2010
Revised: May 24, 2010
Accepted: May 31, 2010
Published online: June 26, 2010
Abstract
Clopidogrel has shown an excellent safety, tolerability and efficacy ever since its marketing. However, here we report a rare case with profound thrombocytopenia following clopidogrel administration previously safely exposed to this same drug. This reminds us that thrombocytopenia might be induced by clopidogrel even with a prior, safe history of long-term administration.
Keywords: Clopidogrel, Thrombocytopenia, Coronary artery disease, Stent