Novelli G, Predazzi IM, Mango R, Romeo F, Mehta JL. Role of genomics in cardiovascular medicine. World J Cardiol 2010; 2(12): 428-436 [PMID: 21191544 DOI: 10.4330/wjc.v2.i12.428]
Corresponding Author of This Article
Giuseppe Novelli, PhD, Professor, Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy. novelli@med.uniroma2.it
Article-Type of This Article
Review
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World J Cardiol. Dec 26, 2010; 2(12): 428-436 Published online Dec 26, 2010. doi: 10.4330/wjc.v2.i12.428
Role of genomics in cardiovascular medicine
Giuseppe Novelli, Irene M Predazzi, Ruggiero Mango, Francesco Romeo, Jawahar L Mehta
Giuseppe Novelli, Irene M Predazzi, Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy
Giuseppe Novelli, Francesco Romeo, Jawahar L Mehta, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
Giuseppe Novelli, IRCSS, Centro Neurolesi “Bonino Pulejo”, 98100 Messina, Italy
Ruggiero Mango, Francesco Romeo, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Author contributions: Novelli G, Romeo F and Mehta JL conceived, designed and supervised the review; Predazzi IM and Mango R wrote the article.
Supported by Italian Ministry of Health and FILAS Regione Lazio
Correspondence to: Giuseppe Novelli, PhD, Professor, Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy. novelli@med.uniroma2.it
Telephone: +39-6-72596079 Fax: +39-6-20427313
Received: July 17, 2010 Revised: October 25, 2010 Accepted: November 1, 2010 Published online: December 26, 2010
Abstract
As all branches of science grow and new experimental techniques become readily accessible, our knowledge of medicine is likely to increase exponentially in the coming years. Recently developed technologies have revolutionized our analytical capacities, leading to vast knowledge of many genes or genomic regions involved in the pathogenesis of congenital heart diseases, which are often associated with other genetic syndromes, coronary artery disease and non-ischemic cardiomyopathies and channelopathies. The knowledge-base of the genesis of cardiovascular diseases is likely going to be further revolutionized in this new era of genomic medicine. Here, we review the advances that have been made over the last several years in this field and discuss different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases.
