Liu F, Tang SJ, Li ZW, Liu XR, Lv Q, Zhang W, Peng D. Poor oral health was associated with higher risk of gastric cancer: Evidence from 1431677 participants. World J Gastrointest Surg 2024; 16(2): 585-595 [PMID: 38463366 DOI: 10.4240/wjgs.v16.i2.585]
Corresponding Author of This Article
Dong Peng, FAASLD, Academic Editor, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. carry_dong@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fei Liu, Zi-Wei Li, Xu-Rui Liu, Quan Lv, Wei Zhang, Dong Peng, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Shi-Jun Tang, Department of Pediatric Dentistry, Stomatological Hospital of Guizhou Medical University, Guizhou 550000, Guizhou Province, China
Co-first authors: Fei Liu and Shi-Jun Tang.
Author contributions: Liu F and Tang SJ contributed equally to this work. All authors contributed to data collection and analysis, drafting, or revising the manuscript, have agreed on the journal to which the manuscript will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong Peng, FAASLD, Academic Editor, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. carry_dong@126.com
Received: November 2, 2023 Peer-review started: November 2, 2023 First decision: November 30, 2023 Revised: December 26, 2023 Accepted: January 29, 2024 Article in press: January 29, 2024 Published online: February 27, 2024
ARTICLE HIGHLIGHTS
Research background
Gastric cancer (GC) is one of the most common tumours worldwide and the forth leading cause of cancer death. Prevention of GC has become a focal point because of these worrisome numbers. Prevention of GC can be divided into primary prevention (reducing the incidence of GC) and secondary prevention (early detection and treatment). Primary prevention includes smoking cessation, reducing salt intake, increasing fruit and vegetable intake, and other health behaviours, such as oral health behaviours.
Research motivation
The aim of present study is to assess whether there is a relationship between oral health and the risk of GC.
Research objectives
The research objective was to explore the relationship between oral health and GC risk.
Research methods
This study searched five databases to find eligible studies from inception to April 10, 2023. Newcastle-Ottawa Scale score was used to assess the quality of included studies. The quality of cohort studies and case-control studies were evaluated separately in this study. Incidence of GC were described by odds ratio (OR) and 95% confidence interval (CI). Funnel plot was used to represent the publication bias of included studies. We performed the data analysis by StataSE 16.
Research results
A total of 1431677 patients from twelve included studies were enrolled for data analysis in this study. According to our analysis, we found that poor oral health was associated with a high risk of GC (OR = 1.15, 95%CI: 1.02-1.29; I2 = 59.47%, P = 0.00 < 0.01), particularly periodontitis (OR = 1.13, 95%CI: 1.04-1.23; I2 = 0.00%, P < 0.01). Moreover, after subgroup analysis, tooth loss (OR = 1.12, 95%CI: 0.94-1.29; I2 = 6.01%, P > 0.01), gingivitis (OR = 1.19, 95%CI: 0.71-1.67; I2 = 0.00%, P > 0.01), dentures (OR = 1.27, 95%CI: 0.63-1.19; I2 = 68.79%, P > 0.01), or tooth brushing (OR = 1.25, 95%CI: 0.78-1.71; I2 = 88.87%, P > 0.01) had no influence on the risk of GC.
Research conclusions
Oral health status associated with GC risk. People should focus on oral health as it might reduce the incidence of GC.
