Liu LB, Li J, Lai JX, Shi S. Harnessing interventions during the immediate perioperative period to improve the long-term survival of patients following radical gastrectomy. World J Gastrointest Surg 2023; 15(4): 520-533 [PMID: 37206066 DOI: 10.4240/wjgs.v15.i4.520]
Corresponding Author of This Article
Sen Shi, MD, Surgeon, Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646000, Sichuan Province, China. shisen80@163.com
Research Domain of This Article
Surgery
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2023; 15(4): 520-533 Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.520
Harnessing interventions during the immediate perioperative period to improve the long-term survival of patients following radical gastrectomy
Lin-Bo Liu, Jian Li, Jian-Xiong Lai, Sen Shi
Lin-Bo Liu, Sen Shi, Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Lin-Bo Liu, Department of Vascular Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, Sichuan Province, China
Jian Li, Jian-Xiong Lai, Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, Sichuan Province, China
Sen Shi, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou 646000, Sichuan Province, China
Sen Shi, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan Province, China
Author contributions: Liu LB and Li J are equal coauthors of this article; Li J and Shi S designed the review; Liu LB, Lai JX and Li J reviewed the literature; Liu LB and Lai JX drafted the manuscript; Shi S revised the manuscript; All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sen Shi, MD, Surgeon, Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646000, Sichuan Province, China. shisen80@163.com
Received: December 15, 2022 Peer-review started: December 15, 2022 First decision: January 3, 2023 Revised: January 4, 2023 Accepted: March 30, 2023 Article in press: March 30, 2023 Published online: April 27, 2023
Abstract
Although the incidence and mortality of gastric cancer (GC) have been decreasing steadily worldwide, especially in East Asia, the disease burden of this malignancy is still very heavy. Except for tremendous progress in the management of GC by multidisciplinary treatment, surgical excision of the primary tumor is still the cornerstone intervention in the curative-intent treatment of GC. During the relatively short perioperative period, patients undergoing radical gastrectomy will suffer from at least part of the following perioperative events: Surgery, anesthesia, pain, intraoperative blood loss, allogeneic blood transfusion, postoperative complications, and their related anxiety, depression and stress response, which have been shown to affect long-term outcomes. Therefore, in recent years, studies have been carried out to find and test interventions during the perioperative period to improve the long-term survival of patients following radical gastrectomy, which will be the aim of this review.
Core Tip: During the relatively short perioperative period, patients undergoing radical gastrectomy will suffer from various perioperative events, which have been shown to affect long-term outcomes. Therefore, in recent years, studies have been carried out to identify and test interventions during the perioperative period to improve the long-term survival of patients following radical gastrectomy. As the majority of these interventions are already safely applied clinically for other indications, are cost-effective and can be administered conveniently, if the desired survival benefits are prospectively confirmed, considerable economic and social improvements can be achieved at little financial cost.
