Diabetes-induced mechanophysiological changes in the small intestine and colon

Figure 1 Duodenal remodeling in STZ-induced diabetic rats. A: The micro-photographs showed the normal (left) and 4 wk diabetic (right) duodenal histological sections. It clearly demonstrated that the muscle and submucosa layers in the diabetic duodenum became much thicker than in the normal duodenum. The bar is 100 μm; B: The circumferential stress-strain relations; C: The longitudinal stress-strain relations. The stress-strain curves in both directions (B and C) shifted to the left during experimental diabetes indicating the duodenal wall became stiffer during the development of diabetes; D: The mean reduced relaxation function curves in the time period of 600 s. The curves appear in the order of largest-to-smallest G (t) as W4, W1, 4d and N. The stress relaxation of duodenum decreased with the development of experimental diabetes. N: Normal control; 4d: 4 d of diabetes; W1: 1 wk of diabetes; W4: 4 wk of diabetes; W8: 8 wk of diabetes.