Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2017; 8(6): 249-269
Published online Jun 15, 2017. doi: 10.4239/wjd.v8.i6.249
Diabetes-induced mechanophysiological changes in the small intestine and colon
Mirabella Zhao, Donghua Liao, Jingbo Zhao
Mirabella Zhao, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark
Donghua Liao, Jingbo Zhao, Giome Academia, Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus N, Denmark
Author contributions: Zhao M looked for literatures, collected data, wrote manuscript and improved English writing; Liao D looked for literatures and wrote manuscript; Zhao J wrote and revised manuscript.
Supported by Karen Elise Jensens Foundation.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jingbo Zhao, PhD, Associate Professor, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, DK-8200 Aarhus N, Denmark. jingbo.zhao@clin.au.dk
Telephone: +45-78-459012
Received: March 6, 2017
Peer-review started: March 10, 2017
First decision: March 29, 2017
Revised: April 24, 2017
Accepted: May 3, 2017
Article in press: May 5, 2017
Published online: June 15, 2017
Core Tip

Core tip: The disorders of intestine and colon are common in patients with diabetes mellitus (DM). DM induced intestinal and colonic structural and biomechanical remodeling are closely related to motor-sensory abnormalities of gut in DM. These changes due to DM are associated with diarrhea, constipation, gut microbiota modification and colon cancer. Understanding the DM-induced changes in the gut and the clinical consequences provides clinicians with a better understanding of the gastrointestinal disorders in diabetic patients and facilitates the improvement of treatments for these patients.