Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2017; 8(4): 154-164
Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.154
Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.154
Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study
Terra G Arnason, Department of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7K 5E5, Canada
Matthew W Bowen, Kerry D Mansell, Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7K 5E5, Canada
Author contributions: Arnason TG and Mansell KD contributed equally to this work; Arnason TG and Mansell KD designed the research; Bowen MW performed the research, designed the analytical tools and analysed the data; Arnason TG and Mansell KD wrote the paper.
Supported by Department of Medicine, University of Saskatchewan, and the College of Pharmacy and Nutrition, University of Saskatchewan.
Institutional review board statement: The study was reviewed and approved by the University of Saskatchewan Biomedical Research Ethics Board.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kerry D Mansell, BSP, PharmD, MBA, Associate Professor, Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, 104 Clinic Place, Saskatoon, SK S7K 5E5, Canada. kerry.mansell@usask.ca
Telephone: +1-306-9665235 Fax: +1-306-9666377
Received: November 25, 2016
Peer-review started: November 26, 2016
First decision: January 16, 2017
Revised: February 11, 2017
Accepted: February 28, 2017
Article in press: March 2, 2017
Published online: April 15, 2017
Peer-review started: November 26, 2016
First decision: January 16, 2017
Revised: February 11, 2017
Accepted: February 28, 2017
Article in press: March 2, 2017
Published online: April 15, 2017
Core Tip
Core tip: Intermittent fasting (IF) involves limiting food intake into a single 4 to 8 h period, daily. We observed the tolerability, safety and health benefits of IF in 10 type 2 diabetes mellitus (T2DM) patients during a 2-wk IF intervention. Outcomes were measured after the three study phases; baseline, intervention, and follow-up. Although short, the IF phase significantly improved weight loss and fasting glucose levels, was well tolerated, and hypoglycemia was not observed. During follow-up, glucose levels reverted. This simple, outpatient-directed dietary manipulation may prove valuable in T2DM individuals with exercise intolerance, who are resistant to complex diet regimes, or are not at glycemic goals.