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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2021; 12(4): 366-382
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.366
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.366
Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view
Simon Lecoutre, Salwan Maqdasy, Department of Medicine (H7), Karolinska Institutet, Stockholm 141-86, Sweden
Simon Lecoutre, Christophe Breton, University of Lille, EA4489, Maternal Malnutrition and Programming of Metabolic Diseases, Lille 59000, France
Salwan Maqdasy, Clermont-Ferrand CHU, Department of Endocrinology, Diabetology and Metabolic Diseases, Clermont-Ferrand 63003, France
Christophe Breton, U1283-UMR8199-EGID, University of Lille, Institut National de la Santé Et de la Recherche Médicale, Centre National de la Recherche Scientifique, Lille 59000, France
Author contributions: All authors participated in the literature review and analysis, design of the figures, and in writing the review.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christophe Breton, PhD, U1283-UMR8199-EGID, University of Lille, Institut National de la Santé Et de la Recherche Médicale, Centre National de la Recherche Scientifique, CHU Lille, Institut Pasteur de Lille, Lille 59000, France. christophe.breton@univ-lille1.fr
Received: January 16, 2021
Peer-review started: January 16, 2021
First decision: January 24, 2021
Revised: January 30, 2021
Accepted: February 18, 2021
Article in press: February 18, 2021
Published online: April 15, 2021
Peer-review started: January 16, 2021
First decision: January 24, 2021
Revised: January 30, 2021
Accepted: February 18, 2021
Article in press: February 18, 2021
Published online: April 15, 2021
Core Tip
Core Tip: According to the developmental origin of health and disease concept, maternal obesity and neonatal accelerated growth predispose offspring to metabolic diseases. White adipose tissue and pancreatic β-cells are key targets of developmental programming, although the underlying mechanisms remain elusive. Human and rodent studies have contributed to decipher the role of epigenetic mechanisms in the transgenerational inheritance of obesity and type 2 diabetes (T2D). In this review, we discuss the current understanding of the link between obesogenic maternal nutritional environment, developmental epigenetic adipocyte and β-cell remodeling and predisposition to obesity and T2D later in life.