Pharmacologic rationale for treatments of peritoneal surface malignancy from colorectal cancer

Figure 3 Conceptual diagram of tissue adjacent to the peritoneal cavity. C_p = the free drug concentration in the peritoneal fluid; C_B = the free drug concentration in the blood (or plasma). Solid line shows the exponential decrease in the free tissue interstitial concentration, C_e, as the drug diffuses down the concentration gradient and is removed by loss to the blood perfusing the tissue. Also shown are the characteristic diffusion length, x₀, at which the concentration difference between the tissue and the blood has decreased to 37% of its maximum value, and 3x₀, at which the difference has decreased to 5% of its maximum value[36].