Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer

doi:10.4251/wjgo.122057

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 122057
Published online Aug 15, 2026. doi: 10.4251/wjgo.122057

Table 4 Proteasome subunit beta 5 expression and clinicopathological features in colorectal cancer

Parameters	Total number (n = 129)	High expression (n = 98)	Low expression (n = 31)	χ² value	P value
Age (years)
< 60	55	40	15	0.552	0.458
≥ 60	74	58	16	0.552	0.458
Gender
Male	66	50	16	0.003	0.954
Female	63	48	15	0.003	0.954
Tumor size (cm)
< 5	64	48	16	0.065	0.798
≥ 5	65	50	15	0.065	0.798
Differentiation
Well/moderate	105	74	31	9.327	0.002^a
Poor	24	24	0	9.327	0.002^a
Depth of invasion
T1-T2	21	11	10	7.645	0.006^a
T3-T4	108	87	21	7.645	0.006^a
Lymph node metastasis
No	73	45	28	18.902	0.001^a
Yes	56	53	3	18.902	0.001^a
Distant metastasis
No	100	69	31	11.834	0.001^a
Yes	29	29	0	11.834	0.001^a
TNM stage
I-II	61	33	28	30.320	0.001^a
III-IV	68	65	3	30.320	0.001^a

^aP < 0.01.

TNM: Tumor, node, and metastasis.

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Citation: Xu AP, She SP, Xiao YS, Lang J, Yuan JF, Zeng YF. Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 122057
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/122057.htm
DOI: https://dx.doi.org/10.4251/wjgo.122057

Xu AP, She SP, Xiao YS, Lang J, Yuan JF, Zeng YF. Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 122057 [DOI: 10.4251/wjgo.122057]

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