Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer

doi:10.4251/wjgo.122057

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 122057
Published online Aug 15, 2026. doi: 10.4251/wjgo.122057

Table 2 Sequences of the small interfering RNAs in the proteasome subunit beta 5-targeting pool

siRNA name/ID	Target sequence (DNA notation)	Actual synthesized oligo (5’ → 3’)	Target position
siPSMB5-#1	TCGAATCTATGAGCTTCGAAATA	UCGAAUCUAUGAGCUUCGAAAUAdTdT	385-407
siPSMB5-#2	GTGCTTGAAACCTAAGTCATTTG	GUGCUUGAAACCUAAGUCAUUUGdTdT	538-560
siPSMB5-#3	GACTGTCATTGGTAATACGGACA	GACUGUCAUUGGUAAUACGGACAdTdT	935-955
Scramble (siControl)	TTCTCCGAACGTGTCACGTTT	UUCUCCGAACGUGUCACGUdTdT	N/A

All small interfering RNAs were synthesized as RNA oligos with 3’dTdT overhangs. si: Small interfering; PSMB5: Proteasome subunit beta 5; N/A: Not applicable.

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Citation: Xu AP, She SP, Xiao YS, Lang J, Yuan JF, Zeng YF. Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 122057
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/122057.htm
DOI: https://dx.doi.org/10.4251/wjgo.122057

Xu AP, She SP, Xiao YS, Lang J, Yuan JF, Zeng YF. Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 122057 [DOI: 10.4251/wjgo.122057]

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