Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma

Figure 1 Structural characteristics of signal regulatory protein alpha. A: The three-dimensional predicted structure of signal regulatory protein alpha (SIRPα). It contains an intracellular domain, an extracellular domain, and four tyrosine residues in the cytoplasmic region; B: The structure of SIRPα. It contains three immunoglobulin like domains in the extracellular domain. It contains four tyrosine residues in the cytoplasmic region, forming two typical tyrosine immunosuppressive motifs; C: CD47-SIRPα signaling pathway. ITIM: Immunoreceptor tyrosine-based inhibitory motif; SIRPα: Signal regulatory protein alpha. Parts of Figure 1 were created in pymol.