Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

Figure 2 The aberrant fibroblast growth factor 19-fibroblast growth factor receptor 4 axis induces immune suppression. The aberrant fibroblast growth factor 19 (FGF19)-fibroblast growth factor receptor 4 (FGFR4) axis promotes IGF2BP1 expression by activating the PI3K-AKT pathway and can also increase ETV4 expression via the ERK 1/2-ELK 1 pathway. ETV4 can upregulate the expression of FGFR4, forming a positive feedback loop. Overexpression of FGF19 can promote tumor cell proliferation and angiogenesis, leading to a hypoxic microenvironment. Hypoxia-inducible factors can induce upregulation of programmed death-ligand 1 through pathways such as lactic acid, hypoxia-inducible factor-1α-CD39/CD73-adenosine. This ultimately induces immune suppression by reducing infiltration of CD8+ T cells and natural killer cells, polarization of macrophages from the M1 to M2, and increasing infiltration of MDSCs and regulatory T cells. The combination of FGFR4 inhibitors with anti-angiogenic drugs or immune checkpoint inhibitors can enhance the anti-tumor effect. FGF19: Fibroblast growth factor 19; FGFR4: Fibroblast growth factor receptor 4; KLB: Β-klotho; PI3K: Phosphoinositide 3-kinase; AKT: Protein kinase B; IGF2BP1: Insulin-like growth factor 2 mRNA-binding protein 1; RAS: Rat sarcoma; RAF: Rapidly accelerated fibrosarcoma; MEK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; ELK: ETS-like gene; ETV4: E-twenty-six-specific sequence variant 4; MCT4: Monocarboxylate transporter 4; ATP: Adenosine triphosphate; NK cell: Natural killer cell; ICI: Immune checkpoint inhibitor; MDSC: Myeloid-derived suppressor cell; Treg: Regulatory T cell. This figure was created with BioGDP.com[32].