Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

Figure 1 The aberrant fibroblast growth factor 19-fibroblast growth factor receptor 4 axis drives hepatocellular carcinoma. Overexpression of fibroblast growth factor 19 (FGF19) binds to fibroblast growth factor receptor 4 (FGFR4), leading to its phosphorylation and recruitment of FGFR substrate-2 (FRS2), GRB2, and SOS, which subsequently trigger a cascade of downstream effector proteins. The aberrant FGF19-FGFR4 axis primarily promotes tumor growth through the RAS-RAF-MAPK and PI3K-AKT signaling pathways. Additionally, it facilitates the phosphorylation of GSK3β, preventing the inactivation of downstream β-catenin. Activated FGFR4 can also activate the JAK2/STAT3 pathway. Together, these mechanisms promote hepatocellular carcinoma cell proliferation and resistance to apoptosis. Additionally, the FGF19-FGFR4 axis shares similar downstream molecules with the vascular endothelial growth factor receptor pathway. FGF19: Fibroblast growth factor 19; FGFR4: Fibroblast growth factor receptor 4; VEGF: Vascular endothelial growth factor; KLB: Β-Klotho; GRB2: Growth Factor receptor-bound protein 2; SOS: Son of sevenless homolog; FRS2: FGFR substrate-2; SHC: Src homology domain protein C1; JAK: Janus kinase; STAT: Signal transducer and activator of transcription; RAS: Rat sarcoma; RAF: Rapidly accelerated fibrosarcoma; MEK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; PI3K: Phosphoinositide 3-kinase; AKT: Protein kinase B; mTOR: Mechanistic target of rapamycin; GSK3β: Glycogen synthase kinase 3β; C-MYC: Cellular myelocytomatosis; EMT: Epithelial-mesenchymal transition; Bcl-2: B-cell lymphoma 2; IL-6: Interleukin-6; PD-L1: Programmed death-ligand 1. This figure was created with BioGDP.com[32].