Risk prediction of acute variceal bleeding in hepatocellular carcinoma patients undergoing systemic therapy based on immune checkpoint inhibitors

Table 3 Multifactorial logistic regression of factors affecting acute variceal bleeding

Factor	B	SE	Wald χ2	P value	OR (95%CI)
Maximum tumor diameter ≥ 5 cm	1.067	0.466	5.248	0.022	2.908 (1.167-7.246)
Combined portal vein tumor thrombosis	1.104	0.472	5.465	0.019	3.017 (1.195-7.616)
History of pre-treatment bleeding	2.829	0.533	28.143	0.000	16.923 (5.951-48.123)
FIB-4 ≥ 4.57	1.044	0.468	4.973	0.026	2.841 (1.135-7.115)
Constant	-3.587	0.530	45.817	0.000	-

Logistic regression model to predict bleeding: Ln (P/1-P) = 1.067 × maximum tumor diameter (≥ 5 = 1, < 5 = 0) + 1.104 × combined portal vein tumor thrombus (yes = 1, no = 0) + 2.829 × history of pre-treatment bleeding (yes = 1, no = 0) + 1.044 × fibrosis-4 index (≥ 4.565 = 1, < 4.565 = 0) - 3.587. FIB-4: Fibrosis-4 index.