Different titration protocols in pain management after radical gastrectomy for gastric cancer patients

Table 5 Comparison of adverse reactions, %

Characteristic	12-hour titration regimen, n = 52	24-hour titration regimen, n = 68	P value
Incidence of postoperative nausea and vomiting	15	30	0.02
Incidence of respiratory depression	2	8	0.04
Cox regression analysis: Hazard ratio	0.45	1.00	< 0.001
Number of rescue analgesic doses in first 24 hours	1.2	2.1	0.005
Patient satisfaction score, 0-10	8.5	7.2	0.001
Time to first analgesic request, hours	3.5	2.1	0.003
Incidence of dizziness	5	10	0.03
Incidence of sedation	10	18	0.01
Length of hospital stay, days	4.2	4.8	0.020
Pain intensity at 48 hours postoperatively (VAS)	2.1	2.9	0.015
Pain intensity at 72 hours postoperatively (VAS)	1.8	2.5	0.030

VAS: Visual Analog Scale.