Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca2+ pathway

doi:10.4251/wjgo.v17.i8.107453

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2025; 17(8): 107453
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.107453

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Figure 3 Deoxycholic acid promotes the increase of intracellular and mitochondrial calcium ion content in SW480 and DLD-1 cells. A and B: Flow cytometry results and statistics of intracellular calcium content in SW480 and DLD-1 cells, respectively; C and D: Flow cytometry results and statistics of intracellular calcium content in mitochondria of SW480 and DLD-1 cells, respectively; E: Confocal microscopy results of intracellular calcium content in mitochondria of SW480 and DLD-1 cells; F: Western blot results and statistics of p-CaMKII protein in SW480 and DLD-1 cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. PE: Phycoerythrin; FITC: Fluorescein isothiocyanate; DCA: Deoxycholic acid.

Citation: Chen JY, Wen JY, Lin JL, Li Y, Wu YZ, Lou LQ, Lou YL, Zuo ZG, Li X. Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca²⁺ pathway. World J Gastrointest Oncol 2025; 17(8): 107453
URL: https://www.wjgnet.com/1948-5204/full/v17/i8/107453.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i8.107453

Chen JY, Wen JY, Lin JL, Li Y, Wu YZ, Lou LQ, Lou YL, Zuo ZG, Li X. Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca²⁺ pathway. World J Gastrointest Oncol 2025; 17(8): 107453 [PMID: 40837770 DOI: 10.4251/wjgo.v17.i8.107453]

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