Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca2+ pathway

Figure 1 Deoxycholic acid promotes apoptosis in SW480 and DLD-1 cells. A: Flow cytometry results and statistical plots for SW480 and DLD-1 cells; B: Western blot results and statistical plots of apoptosis-related proteins in SW480 and DLD-1 cells, and a histogram of the Cleaved-PARP/PARP ratio analysis. Control represents DMSO treatment, and the experimental group was treated with 100 μM deoxycholic acid for 24 hours. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. PE: Phycoerythrin; DCA: Deoxycholic acid.