GEN1 regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer

doi:10.4251/wjgo.v17.i8.106781

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Aug 15, 2025 (publication date) through Aug 29, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2025; 17(8): 106781
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.106781

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Figure 6 GEN1 downregulation impelled cell ferroptosis in AGS cells. A: The adenosine triphosphate content in AGS cells transfected with negative control with scrambled shRNA cells or shGEN1; B: Dihydroethidium staining analysis of reactive oxygen species production in AGS cells; C: Western blotting detected ACSL4, GPX4, and FTH1 protein levels in AGS cells. ^cP < 0.001. ATP: Adenosine triphosphate; shCtrl: Negative control with scrambled shRNA; sh: Short hairpin; DAPI: 4’,6-diamidino-2-phenylindole; DHE: Dihydroethidium; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.

Citation: Zhang Q, Yuan ZG, Zheng KF, Chen K. GEN1 regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer. World J Gastrointest Oncol 2025; 17(8): 106781
URL: https://www.wjgnet.com/1948-5204/full/v17/i8/106781.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i8.106781