LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway

Figure 4 Long non-coding RNA small nucleolar RNA host gene 5 overexpression improved the severity of gastric cancer in vivo. A: Tumor photographs; B: Body weight change (g); C: Tumor volume (mm³); D: Tumor weight (g); E: Western blot analysis was performed to determine the expression of B-cell translocation gene 2, PI3K, p-PI3K, AKT, and p-AKT. With the ratio of B-cell translocation gene 2/GAPDH, PI3K/GAPDH, p-PI3K/GAPDH, AKT/GAPDH, and p-AKT/GAPDH, the control was defined as 1. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; NC: Negative control; OE-lncRNA SNHG5: Overexpression of long non-coding RNA small nucleolar RNA host gene 5; BTG2: B-cell translocation gene 2.