LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway

Figure 2 Long non-coding RNA small nucleolar RNA host gene 5 overexpression and miR-92a-3p knockdown inhibited the proliferation and migration of gastric cancer cells. A: CCK-8 assay was used to detect the cell activity after long non-coding RNA (lncRNA) small nucleolar RNA host gene 5 (SNHG5) overexpression and miR-92a-3p knockdown; B: The colony formation assay was performed to detect the clonogenic ability of gastric cancer (GC) cells after lncRNA SNHG5 overexpression and miR-92a-3p knockdown; C: Scratch assay was used to detect the wound healing ability of GC cells after lncRNA SNHG5 overexpression and miR-92a-3p knockdown; D: The Transwell assay detected the migration and invasion ability of GC cells after lncRNA SNHG5 overexpression and miR-92a-3p knockdown (× 200 magnification). Scale bar: 100 μm. ^bP < 0.01; ^cP < 0.001; lncRNA: Long non-coding RNA; SNHG5: Small nucleolar RNA host gene 5; NC: Negative control; OE-lncRNA SNHG5: Overexpression of long non-coding RNA small nucleolar RNA host gene 5; sh: Short hairpin; miR: MicroRNA.